isothiosemicarbazide

English[edit]

isothiosemicarbazide (plural isothiosemicarbazides)

(organic chemistry) The isomer of thiosemicarbazide R-S-C(=NH)-NH-NH2 (R=H), or any of its derivatives (R=alkyl or aryl radical)
- 2015 July 14, “Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption”, in PLOS ONE‎^[1], →DOI:
  Among these, proteolytically stable azadipeptide nitriles have been developed, with picomolar Ki value towards the therapeutically relevant cathepsins B, K, L and S with which they form reversible isothiosemicarbazide adducts [24 –26 ].