misdifferentiate

English

Etymology

mis- +‎ differentiate

Verb

misdifferentiate (third-person singular simple present misdifferentiates, present participle misdifferentiating, simple past and past participle misdifferentiated)

1. To fail to differentiate correctly.
   • 2008, Charles J. Epstein, Robert P. Erickson, Anthony Joseph Wynshaw-Boris, Inborn Errors of Development, page 705:

     In the absence of Mxxl, cranial neural crest-derived mesenchyme consequently fails to proliferate and misdifferentiates (Han et al., 2003a).

   • 2013, Theodoulakis Christofi, Yiorgos Apidianakis, “Drosophila and the Hallmarks of Cancer”, in Andreas Vilcinskas, editor, Yellow Biotechnology I: Insect Biotechnologie in Drug Discovery and Preclinical Research, page 100:

     Sumoylation-deficient Drosophila lesswright mutants have been shown to induce overproduction of hemocytes and form melanotic tumors whereas Ubc9 mutations activate progenitors to misdifferentiate, become hyperplastic, and develop microtumors [172, 173].

   • 2020, Ken-Ichi Furakawa, Shunfu Chin, Toru Asari, Kanichiro Wada, Gentaro Kumagai, Yasuyuki Ishibashi, “Ectopic Ossification of Human Spinal Ligaments Caused by Mesenchymal Stem Cell Abnormalities”, in Atsushi Okawa, Morio Matsumoto, Motoki Iwasaki, editors, OPLL: Ossification of the Posterior Longitudinal Ligament, page 47:

     Mesenchymal stem cells of patients with ossification are thought to misdifferentiate into osteoblasts instead of target ligament cells because they have high osteogenic ability.